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In the words of Russell Wesdyk, associate director in the FDA's drug center: "There's no way to know what the substance actually is, was or will be tomorrow because that name has no legal meaning" [20]

GLP-1 may affect systemic energy metabolism by regulating adipocyte development, accelerating plasma clearance of glucose and triacylglycerol-derived fatty acids, improving insulin signaling, and stimulating thermogenesis in brown adipose tissue (BAT) [40-45]